Once unlocked, the Polaroid and Negative will always drop when you beat Mom, but you can only pick up one of them. Each of these 5 times CAN be with the same character every time, but you will need to beat everything with every character eventually to unlock everything. But every time you beat It Lives, the entrances to both Sheol and The Cathedral open up, letting you choose where to go.įrom there, beat Cathedral 5 times to unlock the Polaroid, and Sheol 5 times for the Negative. It permanently replaces Mom's Heart and is a bit tougher. The 11th time you beat Mom's Heart, you unlock it's alternate form "It Lives". Early on, you can only go past The Womb if you manage to get an Angel or Devil room after fighting Mom's Heart. is your best friend.īut I'll answer here too. NEVER TAKE ISAAC'S HEART AFTER THE FIRST TIME! It's soooooo bad.įor almost every question. I also may have missed some other things too.Now me personally, I (almost) always take Bob's Brain and I always take Experimental Treatment. I'm sure others will put in their two cents, so yeah. Breath of Life (Luckily this one is an active item, so you can drop it eventually) Experimental Treatment (I take it most of the time.) It can kill you if you're playing as Blue Baby though
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Fetus (Which should be patched whenever Afterbirth DLC releases, but for now avoid at all costs.) There are certain items I recommend nobody pick up really unless they're feeling feisty, or they're trying to achieve Real Platinum God. I'd recommend trying to experience as much as you can before using it though.ĥ. Seems self-explanatory, but I figured I'd throw it in there.Ĥ. Learn to dodge, and learn enemy patterns. Never/rarely cross the spikes in Sacrifice Roomsģ. (you actually need to die 100 times to unlock one of the items, so yeah.)Ģ. I got Real Platinum God on the Steam version after almost 200 hours and I still love this game You'll get better, and have a lot of fun unlocking and finding new things all the time. GIANT LASERS EVERYWHEREĪlso Bob's Brain is a piece of shit, and loves to show up many times in a single run if you don't pick it up.īut really, just play play play. Brimstone+Tammy's Head is my personal favorite. You will eventually start to learn what items you like and don't like, and which ones synergize nicely together.
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Some items only unlock if you pick up multiple specific items in a single run, such as Guppy's Hairball from picking up 3 Guppy items, or Little Baggy from picking up multiple drug-themed items.
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It's worth picking up every new item at least once, just so you can know what it does, and get progress towards Real Platinum God. Side tip: if you have flying, you can enter the room without taking damage, but you still get hurt on the way out. But if you have decent health, it's almost always worth checking out. Occasionally though, it will just have some spiders in it. They quite often have one or two red chests and sometimes a stone chest, or sometimes can even have a Devil Room item for free.